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Tamsulosin Hydrochloride is an alpha-blocker medication used to treat benign prostatic hyperplasia (BPH), a condition in which the prostate gland becomes enlarged and causes urinary problems. It works by relaxing the muscles in the prostate and bladder neck, allowing urine to flow more easily.
Mechanism of Action
Tamsulosin hydrochloride acts as an alpha-1 adrenergic receptor antagonist with selectivity for the alpha-1A subtype. It blocks these receptors primarily in the prostate and bladder neck, leading to relaxation of the smooth muscle fibers in these areas. This results in decreased urethral resistance and improved urine flow, alleviating symptoms associated with benign prostatic hyperplasia (BPH).
Indications
Tamsulosin hydrochloride is indicated for the management of lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). It helps to improve urinary flow and reduce symptoms such as difficulty initiating urination, frequency, urgency, nocturia (nighttime urination), and interrupted urine stream.
| English name: | Tamsulosin Hydrochloride |
| English alias: | Tamsulosin HCL; 5-[(2R)-2-[[2-(2-Ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzenesulfonamide hydrochloride; 5-[(2R)-2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl]-2-methoxybenzenesulfonamide hydrochloride; 5-(2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl)-2-methoxybenzenesulfonamide hydrochloride; (-)-(R)-5-[2-[2-(2-Ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzenesulfonamide hydrochloride; Tamuzosin hydrochloride |
| CAS Number: | 106463-17-6;80223-99-0 |
| Molecular formula: | C20H29ClN2O5S |
| Molecular weight: | 444.9727 |
| InChI: | InChI=1/C20H28N2O5S.ClH/c1-4-26-17-7-5-6-8-18(17)27-12-11-22-15(2)13-16-9-10-19(25-3)20(14-16)28(21,23)24;/h5-10,14-15,22H,4,11-13H2,1-3H3,(H2,21,23,24);1H |
| Melting point: | 228-230℃ |
| Boiling point: | 595.5°C at 760 mmHg |
| Flash point: | 313.9°C |
| Steam pressure: | 3.79E-14mmHg at 25°C |
