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Topiroxostat is a medication that belongs to the class of drugs known as xanthine oxidase inhibitors. It is primarily used to treat hyperuricemia (high levels of uric acid in the blood) and gout by inhibiting the enzyme xanthine oxidase, which plays a key role in the production of uric acid. The drug works by blocking the conversion of hypoxanthine and xanthine to uric acid, thereby reducing uric acid levels in the blood.
Mechanism of Action
Topiroxostat exerts its effects by inhibiting the enzyme xanthine oxidase, which is responsible for the final step in the purine degradation pathway, converting hypoxanthine to xanthine and then xanthine to uric acid. By inhibiting this enzyme, Topiroxostat reduces the production of uric acid, leading to decreased uric acid levels in the blood and urine. This mechanism helps to prevent the formation of urate crystals in joints, which can cause inflammation and pain associated with gout.
Indications
It is commonly prescribed for the management of hyperuricemia and gout, particularly in patients who require additional control of uric acid levels beyond lifestyle modifications and diet. In some cases, it may also be used off-label for other conditions related to elevated uric acid levels under close medical supervision.
| English name: | Topiroxostat |
| English alias: | FYX051;Topiroxostat;Topiroxostat,FYX-051;5-(2-Cyano-4-pyridyl)-3-(4-pyridyl)-1,2,4-triazole;Topiroxostat5-(2-Cyano-4-pyridyl)-3-(4-pyridyl)-1,2,4-triazolChemicalbooke;4-[5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl]pyridine-2-carbonitrile;2-Pyridinecarbonitrile,4-[5-(4-pyridinyl)-1H-1,2,4-triazol-3-yl]-;Topiroxostatimpurty |
| CAS Number: | 577778-58-6 |
| EINECS Number: | 1592732-453-0 |
| Molecular formula: | C13H8N6 |
| Molecular weight: | 248.24 |
| InChI: | InChI=1S/C13H8N6/c14-8-11-7-10(3-6-16-11)13-17-12(18-19-13)9-1-4-15-5-2-9/h1-7H,(H,17,18,19) |
| Density: | 1.45±0.1 g/cm3(Predicted) |
| Boiling point: | 594.7±60.0 °C(Predicted) |
