close
Choose Your Site
Global
Social Media
Silodosin is a medication that belongs to the class of drugs known as alpha-blockers. It is primarily used to treat the symptoms of benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS). The drug works by selectively blocking alpha-1A adrenergic receptors in the prostate and bladder neck, which helps to relax the muscles and improve urine flow.
Mechanism of Action
Silodosin exerts its effects by selectively blocking alpha-1A adrenergic receptors in the prostate and bladder neck. By blocking these receptors, Silodosin reduces the tone of the smooth muscle fibers in these areas, leading to relaxation and improved urine flow. This mechanism helps to alleviate the symptoms of BPH and LUTS, such as difficulty urinating, frequent urination, and urgency.
Indications
It is commonly prescribed for the management of benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS), particularly in patients with an enlarged prostate gland. In some cases, it may also be used off-label for other conditions under close medical supervision.
English name: | Silodosin |
English alias: | 1-(3-Hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-2,3-dihydro-1H-indole-7-carboxamide; 1-(3-hydroxypropyl)-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}amino)propyl]-2,3-dihydro-1H-indole-7-carboxamide; (-)-1-(3-Hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-2,3-di-hydro-1H-indole-7-carboxamide; KAD 3213; KMD 3213; 1H-Indole-7-carboxamide,2,3-dihydro-1-(3-hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]- |
CAS Number: | 160970-54-7;160970-64-9 |
EINECS Number: | 814-909-2 |
Molecular formula: | C25H32F3N3O4 |
Molecular weight: | 495.5345 |
InChI: | InChI=1/C25H32F3N3O4/c1-17(30-8-12-34-21-5-2-3-6-22(21)35-16-25(26,27)28)13-18-14-19-7-10-31(9-4-11-32)23(19)20(15-18)24(29)33/h2-3,5-6,14-15,17,30,32H,4,7-13,16H2,1H3,(H2,29,33)/t17-/m1/s1 |
Density: | 1.249g/cm3 |
Boiling point: | 601.4°C at 760 mmHg |
Flash point: | 317.5°C |
Steam pressure: | 2.58E-15mmHg at 25°C |
